The ultimate goal in developing new synthetic methodologies in organic chemistry is to create molecular complexity from simple organic fragments in a minimum number of steps. Transition metal catalysis is one very powerful technique allowing difficult transformations by lowering the energy barrier and controlling the chemoselectivity and the stereochemical outcome of the reaction. Alkynes are very reactive and easily accessible organic functional groups which can be functionalized by various transition metal catalyzed transformations such as pericyclic reactions, carbonylation, hydroarylation, hydroamination, and many others. However, due to their very weak polarization, the functionalization of simple alkynes is difficult to control with a high level of regio- and stereoselectivity. With the project HydroMet, we would like to investigate further the transition metal-catalyzed hydrometallation of polarized triple C≡C bonds substituted by heteroatoms or functional groups and develop efficient methodologies to make this reaction regio- and stereoselective.
This project is funded by the Agence Nationale de la Recherche (ANR-18-CE07-0020)
With complementary reactivities under radical, ionic, and metal-catalyzed conditions, ynamides are fascinating small molecules. We developed synthetic and DFT investigations of palladium-catalyzed ligand-controlled regiodivergent hydrometalation reactions of ynamides. Germylated and stannylated enamides are obtained with excellent α,E– or β,E-selectivities and a broad functional group tolerance. Such a regiodivergent palladium-catalyzed process is unique in ynamide chemistry and allows for the elaboration of metalated enamides that are useful building blocks for cross-coupling reactions or heterocyclic chemistry. In collaboration with Prof. K. N. Houk from the University of California (USA), DFT calculations fully support the experimental data and demonstrate the crucial roles of the trans-geometry of the [H-Pd(L)-Ge] complex, as well as of the steric requirements of the phosphine ligand. In addition, these calculations support the prevalence of a hydro-palladation pathway over a metal palladation of the π system of the ynamide.
J. Am. Chem. Soc. 2020, 142, 25, 11153–11164 (link)
Nous recherchons un post-doc pour de la synthèse de produits naturels par catalyse à l'ADN dans le cadre de l'ANR Smash. Retweetez si vous pouvez. We are seeking for a postdoc associate.
Group website is now updated!
*2 offers for post-doctoral positions
*1 search for candidates for the doctoral school competition in chemical science
We look forward to hearing from you!
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@LIMA_UMR7042 @CNRS_Alsace @BizetVincent
The group is looking for candidates for the @unistra 2023 Chemistry Doctoral School Competition ! We propose to further dive into Diels-Alder chemistry. Interested ? Want to know more? Short abstract in the link below. @LIMA_UMR7042
Group website is now updated!
*2 offers for post-doctoral positions
*1 search for candidates for the doctoral school competition in chemical science
We look forward to hearing from you!
More details here: https://bsm.unistra.fr/join-the-group/
@LIMA_UMR7042 @CNRS_Alsace @BizetVincent
A second post-doc position is now available in the group, on total synthesis of natural products analogs. Want to dive into mycolactone chemistry? We're waiting for you!
Details and application on the CNRS website (deadline April 10) https://emploi.cnrs.fr/Offres/CDD/UMR7042-NICBLA-001/Default.aspx?lang=EN @LIMA_UMR7042
You want to join the LIMA @ECPM_Unistra to obtain your PhD? 10 subjects are open in our department to pass the competition of the doctoral school (ED222) @unistra. There is something for everyone (as long as you love molecular chemistry :-)))
http://ed.chimie.unistra.fr/fileadmin/upload/DUN/edsc/03_Financement/2023-Contrats_doctoraux/Final-_2023_Contrats_Doctoraux_-_liste_des_sujets.pdf
Des 3-benzylménadiones (E. Davioud-Charvet, @LIMA) antipaludiques sont testées au @CERMEL (Akim Adegnika, et Steffen Borrmann, Tübingen-Lambaréné) par Stéphanie Blandin (IBMC, @CNRS) et al. sur des souches de Plasmodium spp.
Today we have the pleasure to listen Frédéric Leroux @Leroux_group to tell us more about the development of strategies towards fluoroalkylated building blocks for industrial application
@SynBioF_COBRA @insarouen @univrouen @CNRS_PN
Group website is now updated!
*2 offers for post-doctoral positions
*1 search for candidates for the doctoral school competition in chemical science
We look forward to hearing from you!
More details here: https://bsm.unistra.fr/join-the-group/
@LIMA_UMR7042 @CNRS_Alsace @BizetVincent