2023-01- Radical Cyclization of Ynamides to Nitrogen Heterocycles
An efficient radical cyclization of suitably functionalized ynamides to nitrogen-containing heterocycles is reported. Upon reaction with tributyltin hydride in the presence of catalytic amounts of AIBN in toluene at 80 °C, a range of ynamides bearing a N-iodopropyl chain could be smoothly cyclized, in a highly regio- and stereo- selective manner, to the corresponding 2-arylidene-pyrrolidines in good to excellent yields. The exocyclic double bond was in addition shown to be an excellent anchor for further chemical diversification and the generality of this radical cyclization could be highlighted by its extension to the synthesis of other nitrogen heterocycles including piperidines, azepanes, pyrazolidines and hexahydropyridazines.
2023-02- Regio- and Stereoselective Hydroelementation of SF5-Alkynes and Further Functionalizations
Herein is described a fully regio- and stereoselective hydroelementation reaction of SF5-alkynes with N, O and S-nucleophiles and further functionalization of the corresponding Z-(hetero)vinyl-SF5 intermediates, a suitable platform to access α-SF5 ketones and esters, β-SF5 amines and alcohols under mild reaction conditions. Experimental and computational comparative studies between SF5– and CF3-alkynes have been performed to highlight and explain the difference of reactivity and selectivity observed between these two fluorinated motifs.
Nous recherchons un post-doc pour de la synthèse de produits naturels par catalyse à l'ADN dans le cadre de l'ANR Smash. Retweetez si vous pouvez. We are seeking for a postdoc associate.
Group website is now updated!
*2 offers for post-doctoral positions
*1 search for candidates for the doctoral school competition in chemical science
We look forward to hearing from you!
More details here: https://bsm.unistra.fr/join-the-group/
@LIMA_UMR7042 @CNRS_Alsace @BizetVincent
The group is looking for candidates for the @unistra 2023 Chemistry Doctoral School Competition ! We propose to further dive into Diels-Alder chemistry. Interested ? Want to know more? Short abstract in the link below. @LIMA_UMR7042
Group website is now updated!
*2 offers for post-doctoral positions
*1 search for candidates for the doctoral school competition in chemical science
We look forward to hearing from you!
More details here: https://bsm.unistra.fr/join-the-group/
@LIMA_UMR7042 @CNRS_Alsace @BizetVincent
A second post-doc position is now available in the group, on total synthesis of natural products analogs. Want to dive into mycolactone chemistry? We're waiting for you!
Details and application on the CNRS website (deadline April 10) https://emploi.cnrs.fr/Offres/CDD/UMR7042-NICBLA-001/Default.aspx?lang=EN @LIMA_UMR7042
You want to join the LIMA @ECPM_Unistra to obtain your PhD? 10 subjects are open in our department to pass the competition of the doctoral school (ED222) @unistra. There is something for everyone (as long as you love molecular chemistry :-)))
http://ed.chimie.unistra.fr/fileadmin/upload/DUN/edsc/03_Financement/2023-Contrats_doctoraux/Final-_2023_Contrats_Doctoraux_-_liste_des_sujets.pdf
Des 3-benzylménadiones (E. Davioud-Charvet, @LIMA) antipaludiques sont testées au @CERMEL (Akim Adegnika, et Steffen Borrmann, Tübingen-Lambaréné) par Stéphanie Blandin (IBMC, @CNRS) et al. sur des souches de Plasmodium spp.
Today we have the pleasure to listen Frédéric Leroux @Leroux_group to tell us more about the development of strategies towards fluoroalkylated building blocks for industrial application
@SynBioF_COBRA @insarouen @univrouen @CNRS_PN
Group website is now updated!
*2 offers for post-doctoral positions
*1 search for candidates for the doctoral school competition in chemical science
We look forward to hearing from you!
More details here: https://bsm.unistra.fr/join-the-group/
@LIMA_UMR7042 @CNRS_Alsace @BizetVincent