Dr Vincent Bizet

Vincent Bizet studied chemistry at the University of Caen (FR) and then moved to the INSA of Rouen (FR) to do his PhD under the supervision of Dr. D. Cahard (2009-2012). After postdoctoral studies at RWTH Aachen University  (DE) with Prof. C. Bolm (2013-2014 – Alexander von Humboldt fellowship) and then at Geneva University (CH) with Prof. C. Mazet (2014-2016), he joined the CNRS as « Chargé de recherche » at the University of Strasbourg (FR) in 2016 in the team « Biomolecules, Synthesis and Methodologies » (BSM) led by Dr. N. Blanchard from the « Laboratoire d’Innovation Moléculaire et Applications » (LIMA, UMR 7042). In 2022, Vincent obtained his habilitation (HDR) from the University of Strasbourg.
LinkedIn ORCID 0000-0002-0870-1747
  vbizet@unistra.fr
  (+33) 3 89 33 68 38
CV:  
Research topics:
His research interest currently focus on the development of new synthetic methodologies with a special focus on transition metal-catalyzed transformations and fluorine chemistry.
Duties:
– Training correspondent of the LIMA research unit
– LIMA conferences organizer
– Early Career Advisory Board member for Tetrahedron and Tetrahedron Letters

 

Teaching:
– Master 1-S2: Catalysis
– Master 1-S2: Heterochemistry
– Master 2-S4: Fluorine Chemistry

 

Awards:
– 2022 Prix Guy Ourisson 2022 (Cercle Gutenberg)
– 2023 Thieme Chemistry Journals Award
– 2023 Emergence@INC CNRS
 
Nb of publication: 44          Nb of book chapter: 4          Citations: >1500          H-index = 22
 
List of publications:
44) Synthesis of Pentafluorosulfanylated Ynamides and Further Functionalizations
Popek, L.; Lefebvre, G.; Debrauwer, V.; Roubaud, D.; Blanchard, N.; Meyer, C.; Bizet, V. Org. Lett. 2024, DOI:10.1021/acs.orglett.4c03972
43) Recent achievements in the synthesis and reactivity of pentafluorosulfanyl-alkynes
René, F.; Clément–Comoy, L.; Blanchard, N.; Bizet, V. Comptes Rendus. Chimie 2024, 27, 227-240.
42) Stereodivergent Hydrohalogenation of SCF3 Alkynes and Cross- Coupling Reactions
Marie, N.; Uyen Ly, K.; Shibata, N.; Bizet, V.; Cahard D. Org. Lett. 2024, 26, 9168–9172
41) Recent advances in the chemistry and the application of SF5-compounds
Abd El Sater, M.; Popek, L.; Blanchard, N.; Bizet, V. Synthesis 2024, in press 
40) Ambiphilic Reactivity of SF5-Alkynes Applied to Regioselective and Stereodivergent Halogenation Reactions: An Experimental and Theoretical Case Study) Expanding Radical Chloropentafluorosulfanylation of Alkynes
Matchavariani, D.; Popek, L.; Cabrera Trujillo, J. J.; Nguyen, T. M.; Blanchard, N.; Miqueu, K.; Cahard, D.; Bizet, V. Adv. Synth. Catal., 2024, 366, 3481-3493. Special issue: Fluorine Chemistry (link).
39) Expanding Radical Chloropentafluorosulfanylation of Alkynes
Nguyen, T. M.; Popek, L.; Matchavariani, D.; Blanchard, N.; Bizet, V.; Cahard, D. Org. Lett., 2024, 26, 365-369.
38) Palladium-Catalyzed Regioselective Synthesis of 2-SF5-Indenols and Further Derivatizations
Popek, L.; Cihan, M.; Blanchard, N.; Bizet V. Angew. Chem. Int. Ed., 2024, 63, e202315909.
Frontispiece: Angew. Chem. Int. Ed., 2024, 63,  e202480762 (Link).
37) Copper-Catalyzed Regiodivergent Borylation of Fluorinated Alkynes and Palladium-Catalyzed Regiospecific Suzuki-Miyaura cross-coupling
Rummler, L.; Abd El Sater, M.; Blanchard, N.; Bizet, V. Synlett, 2024, 35, 1107-1112.
Special issue: Thieme Chemistry Journals Awardees 2023 (link).
36) Divergent Synthesis of 6- or 7-Aza-Indazoles via Intramolecular Diels–Alder Cascade of Pyrazines Brach, N.; Popek, L.; Truong, M.; Laurent, C.; Bizet, V.; Kaliappan, K. P.; Blanchard, N. Org. Lett. 2023, 25, 7847-7851.
Highlighted in: Synfacts 2024, 20, 128 (link).
35) Un point sur N° 108 – Le SF5 : un groupe fluoré à grand potentiel
Popek, L.; Matchavariani, D.; Bizet, V. L’actualité chimique, N° 488, Octobre 2023.
34) Tracking SF5I in the Iodopentafluorosulfanylation of Alkynes 
Nguyen, T. M.; Legault, C. Y.; Blanchard, N.; Bizet, V.; Cahard, D. Chem. Eur. J. 2023, 29, e202302914.
33) Copper-Catalyzed, Ligand-Controlled N(sp3)- or N(sp)-Selective Arylation of Cyanamides 
Fang, J.; Bekkouch, O.; Zeiser, G.; Zubchuk, Y.; Bizet, V.; Blanchard, N.; Evano, G. Org Lett. 2023, 25, 6446–6451.
32) Regio- and Stereoselective Hydroelementation of SF5-Alkynes and Further Functionalizations  Popek, L.; Cabrera-Trujillo, J. J.; Debrauwer, V.; Blanchard, N.; Miqueu, K.; Bizet, V. Angew. Chem. Int. Ed., 2023, 62, e202300685. Highlighted in:  Actualités de l’INC CNRS, 18 avril 2023 (link).
31) Synthesis and further use of SF5-alkynes as platforms for the design of more complex SF5-containing products 
Popek, L.; Nguyen, T.-M.; Blanchard, N.; Cahard, D.; Bizet, V. Tetrahedron 2022, 117-118, 132814.
30) Synthesis and Physicochemical Properties of 2-SF5-(Aza)Indoles, a New Family of SF5 Heterocycles
Debrauwer, V.; Leito, I.; Lõkov, M.; Tshepelevitsh, S.; Parmentier, M.; Blanchard, N.; Bizet, V. ACS Org. Inorg. Au 2021, 1, 43-50.
29) Ligand-Controlled Regiodivergent PalladiumCatalyzed Hydrogermylation of Ynamides
Debrauwer, V.; Turlik, A.; Rummler, L.; Prescimone, A.; Blanchard, N.; Houk, K. N.; Bizet, V. J. Am. Chem. Soc. 2020, 142, 11153-11164.
Highlighted in:  Actualités de l’INC CNRS, 9 octobre 2020 (link).
28) Pentafluorosulfanyl chloride  
Burton, D. J; Wang, Y.; Bizet, V.; Cahard, D. e-EROS Encyclopedia of Reagents for Organic Synthesis. Wiley, 2020, DOI:10.1002/047084289X.rn00413.pub2.
27) Optimized Synthesis of 7-Azaindazole by a Diels–Alder Cascade and Associated Process Safety
Brach, N.; Le Fouler, V.; Bizet, V.; Lanz, M.; Gallou, F.; Bailly, C.; Hoehn, P.; Parmentier, M.; Blanchard N.  Org. Process Res. Dev. 2020, 24, 776-786.
26) Activating Pyrimidines by Pre-distortion for the General Synthesis of 7-Aza-indazoles from 2-Hydrazonylpyrimidines via Intramolecular Diels–Alder Reactions
Le Fouler, V.; Chen, Y.; Gandon, V.; Bizet, V.; Salomé, C.; Fessard, T.; Liu, F.; Houk, K. N.; Blanchard N.  J. Am. Chem. Soc. 2019, 141, 15901-15909. Highlighted in:  Actualités de l’INC CNRS, 21 octobre 2019 (link).
25) Acid Fluorides in Transition‐Metal Catalysis: A Good Balance between Stability and Reactivity
Blanchard N.; Bizet, V.  Angew. Chem. Int. Ed. 2019, 58, 6814-6817.
24) Diels–Alder and Formal Diels–Alder Cycloaddition Reactions of Ynamines and Ynamide
Duret, G.; Le Fouler, V.; Bisseret, P.; Bizet, V.; Blanchard N. Eur. J. Org. Chem 2017, 6816-6830.
23) Mechanistic Investigation of the Pd-Catalyzed Intermolecular Carboetherification and Carboamination of 2,3-Dihydrofuran: Similarities, Differences and Evidence for Unusual Reaction Intermediates
Borrajo Calleja, G. M.; Bizet, V.; Besnard, C.; Mazet C.  Organometallics 2017, 36, 3553-3563.
22) Influence of the dissolution solvent on the cytotoxicity of octahedral cationic Ir(III) hydride complexes
Huang, H.; Humbert, N.; Bizet, V.; Patra, M.; Chao, H.; Mazet, C.; Gasser G. J. Organomet. Chem. 2017, 839, 15-18.
21) Direct Access to Furoindolines by Palladium-Catalyzed Intermolecular Carboamination
Bizet, V.; Borrajo Calleja, G. M.; Besnard, C.; Mazet C. ACS Catal. 2016, 6, 7183-7187.
Highlighted in: Synfacts 2016, 12, 1257 (link).
20) Palladium Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans
Borrajo Calleja, G. M.; Bizet, V.; Mazet C. J. Am. Chem. Soc. 2016, 138, 4014-4017.
Highlighted in: Synfacts 2016, 12, 591 (link).
19) Access to Enantioenriched 2,3- and 2,5-Dihydrofurans With a Fully substituted C2 Stereocenter by Pd-Catalyzed Asymmetric Intermolecular Heck Reaction
Borrajo Calleja, G. M.; Bizet, V.; Bürgi, T.; Mazet C. Chem. Sci. 2015, 6, 4807-4811.
Highlighted in: Synfacts 2015, 10, 1075 (link).
18) Sulfur Imidations: Access to Sulfimides and Sulfoximines
Bizet, V.; Hendrix, C. M. M.; Bolm, C. Chem. Soc. Rev. 2015, 44, 3378-3390.
17) Direct Access to N-Alkyl Sulfoximines from Sulfides by a Sequential Imidation/Oxidation Procedure
Dannenberg, C. A.; Bizet, V.; Bolm, C. Synthesis 2015, 47, 1951-1959.
16) Sulfur Imidations by Light-Induced Ruthenium-Catalyzed Nitrene Transfer Reactions
Bizet, V.; Bolm, C. Eur. J. Org. Chem. 2015, 2854-2860.
15) Transition-Metal-Free Oxidative Iodination of 1,3,4-Oxadiazoles
Dannenberg, C. A.; Bizet, V.; Zou, L. H.; Bolm, C. Eur. J. Org. Chem. 2015, 77-80.
14) Methionine and Buthionine Sulfoximine: Syntheses under Mild and Safe Imidation/Oxidation Conditions
Buglioni, L.; Bizet, V.; Bolm, C. Adv. Synth. Catal. 2014, 356, 2209-2213.
13) Fluorine as a Control Element in Asymmetric Synthesis
Bizet, V.; Cahard, D. Chimia 2014, 68, 378-381.
12) Light-Induced Ruthenium-Catalyzed Nitrene Transfer Reactions: A Photochemical Approach towards N-Acyl Sulfimides and Sulfoximines
Bizet, V.; Buglioni, L.; Bolm, C. Angew. Chem. Int. Ed. 2014, 53, 5639-5642.
11) Fluorinated sulfoximines : syntheses, properties and applications
Bizet, V.; Kowalczyk, R.; Bolm, C. Chem. Soc. Rev. 2014, 43, 2426-2438.
10) Recent progress in asymmetric fluorination and trifluoromethylation reactions
Bizet, V.; Besset, T.; Ma, J.-A.; Cahard, D. Curr. Top. Med. Chem. 2014, 14, 901-614.
9) The influence of fluorine in asymmetric catalysis
Bizet, V.; Cahard, D. Chem. Soc. Rev. 2014, 43, 135-147.
8) Iron (II) complexes are suitable catalysts for the isomerization of trifluoromethylated allylic alcohols. Synthesis of trifluoromethylated dihydrochalcones
Cahard, D.; Bizet, V.; Dai, X.; Gaillard, S.; Renaud, J.-L. J. Fluorine Chem. 2013, 155, 78-82.
7) Isomérisation rédox : une réaction économe en atomes à fort potentiel d’innovation
Bizet, V.; Cahard, D.; Gaillard, S.; Renaud, J.-L. Les Techniques de l’Ingénieur 2013, IN 159.
6) Ruthenium-catalyzed one-pot tandem isomerization–transfer hydrogenation reactions of γ-trifluoromethylated allylic alcohols and β-trifluoromethylated enones
Bizet, V.; Pannecoucke, X.; Renaud, J.-L.; Cahard, D. Adv. Synth. Catal. 2013, 355, 1394-1402 (Corrigendum 2013, 355, 2113).
5) Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization
Bizet, V.; Pannecoucke, X.; Renaud, J.-L.; Cahard, D. J. Fluorine Chem. 2013, 152, 56-61.
4) N-Fluorobenzensulfonimide
Bizet, V. Synlett 2012, 23, 2719-2720.
3) Ruthenium catalyzed redox isomerization of trifluoromethylated allylic alcohols: mechanistic evidence for an enantiospecific pathway
Bizet, V.; Pannecoucke, X.; Renaud, J.-L.; Cahard, D. Angew. Chem. Int. Ed. 2012, 51, 6467-6470.
Highlighted in: CNRS, en direct des laboratoires de l’institut de chimie (Link).
2) Synthesis of α-CF3-substituted carbonyl compounds with relative and absolute stereocontrol using electrophilic CF3-transfer reagents Matoušek, V.; Togni, A.; Bizet, V.; Cahard, D. Org. Lett. 2011, 13, 5762-5765.
Highlighted in: Synfacts 2012, 8, 81 (link).
1) Metal-Free SN2′ Decarboxylative Rearrangement of β-Keto Esters
Bizet, V.; Lefebvre, V.; Baudoux, J.; Lasne, M.-C.; Boulangé, A.; Leleu, S.; Franck, X.; Rouden, J. Eur. J. Org. Chem. 2011, 4170-4175.
List of book chapters:
1) Asymmetric fluorination methods and their application for the stereoselective synthesis of fluorinated drugs
Bizet, V.; Cahard, D. in « Stereoselective Synthesis of Drugs and Natural Products » (Chapter 44), Ed. Wiley-Blackwell. 2013, ISBN: 978-1-1180-3217-6, pp. 1347-1376.
2) Oxetanes and Oxetenes: Fused-Ring Derivatives
Blanchard, N.; Bizet, V.; Brach, N.; Rummler, L.; Kaliappan, K. P. in Comprehensive Heterocyclic Chemistry IV, Vol. 2 (Eds.: D. S. Black, J. Cossy, C. V. Stevens), Elsevier, Oxford, 2022, pp. 257-286.
3) Radical Reactions of Ynamides
Yang, Q.; Singh, D.; Debrauwer, V.; Bizet, V.; Blanchard, N., Chapter 5 in The Chemistry of Ynamides (Eds.: G. Evano, J. Zhao), Taylor & Francis, 2024, pp. 267-295.
4) Pericyclic Reactions of Ynamides  
Rummler, L.; Brach, N.; Delmée, P.; Charton, L.; Bizet, V.; Blanchard, N. Chapter 9 in The Chemistry of Ynamides (Eds.: G. Evano, J. Zhao), Taylor & Francis, 2024, pp. 511-584.
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