Articles published since 2018 are displayed on this page. For the full production of each individual member of the group, please visit his/her personal page.
2025
Straightforward Access to Pentafluorosulfanylated Phenols and Aminophenols via [4 + 2] Diels–Alder Cycloaddition Reaction. Abd El Sater, M.; René, F.; Blanchard, N.; Cabrera-Trujillo, J. J.; Miqueu, K.; Bizet, V. ACS Org. Inorg. Au 2025, 5, 275-287.
Recent advances in the chemistry and the application of SF5-compounds. Abd El Sater, M.; Popek, L.; Blanchard, N.; Bizet, V. Synthesis, 2025, 57, 1117-11137.
2024
Synthesis of pentafluorosulfanylated ynamides and further functionalizations. Popek, L.; Lefebvre, G.; Debrauwer, V.; Roubaud, D.; Blanchard, N.; Meyer, C.; Bizet, V. Org. Lett. 2024, 26, 10369–10375.
Recent achievements in the synthesis and reactivity of pentafluorosulfanyl-alkynes. René, F.; Clément-Comoy, L.; Blanchard, N.; Bizet, V. Compte Rendus Chimie, 2024, 27, 227-240.
Stereodivergent Hydrohalogenation of SCF3 Alkynes and Cross- Coupling Reactions. Marie, N.; Uyen Ly, K.; Shibata, N.; Bizet, V.; Cahard D. Org. Lett.2024, 26, 9168–9172.
Synthesis of N-Alkyl Substituted Benzimidazoquinazolinones. Gaurav G. Dake, G. G.; Blanchard, N.; Kaliappan, K. P. ACS Omega 2024, 9, 33805-33814.
Ambiphilic Reactivity of SF5-Alkynes Applied to Regioselective and Stereodivergent Halogenation Reactions: An Experimental and Theoretical Case Study. Matchavariani, D.; Popek, L.; Cabrera-Trujillo, J. J.; Nguyen, T. M.; Blanchard, N.; Miqueu, K.; Cahard, D.; Bizet, V. Adv. Synth. Catal. 2024, 366, 3481-3493.
Ring-closing enyne metathesis of allylic and propargylic cyanamides. Fang, J.; Laethem, S. V.; Blanchard, N.; Evano, G. ARKIVOC2024, 2, 202312098.
Palladium-Catalyzed Regioselective Synthesis of 2-SF5-Indenols and Further Derivatizations. Popek, L.; Cihan, M.; Blanchard, N.; Bizet V. Angew. Chem. Int. Ed.2024, 63, e202315909.
Expanding Radical Chloropentafluorosulfanylation of Alkynes. Nguyen, T. M.; Popek, L.; Matchavariani, D.; Blanchard, N.; Bizet, V.; Cahard, D. Org. Lett.2024, 26, 365-369.
Copper-Catalyzed Regiodivergent Borylation of Fluorinated Alkynes and Palladium-Catalyzed Regiospecific Suzuki-Miyaura cross-coupling. Rummler, L.; Abd El Sater, M.; Blanchard, N.; Bizet, V. Synlett2024, 35, 1107-1112.
2023
Divergent Synthesis of 6- or 7-Aza-Indazoles Via Intramolecular Diels-Alder Cascade of Pyrazines. Brach, N.; Popek, L.; Laurent, C.; Truong, M.; Bizet, V.; Kaliappan, K. P.; Blanchard, N. Org. Lett. 2023, 25, 7847-7851 [Highlighted by Reed, M.; Péneau, A. Intramolecular Diels–Alder Cascade to Access 6- or 7-Aza-Indazoles. Synfacts 2024, 20, 128).
Tracking SF5I in the Iodopentafluorosulfanylation of Alkynes. Nguyen, T. M.; Legault, C. Y.; Blanchard, N.; Bizet, V.; Cahard, D. Chem. Eur. J.2023, e202302914.
Copper-Catalyzed, Ligand-Controlled N(sp3)- or N(sp)-Selective Arylation of Cyanamides. Fang, J.; Bekkouch, O.; Zeiser, G.; Zubchuk, Y.; Bizet, V.; Blanchard, N.; Evano, G. Org. Lett.2023, 25, 6446-6451.
A common mechanism of Sec61 translocon inhibition by small molecule. Itskanov, S.; Wang, L.; Junne, T.; Sherriff, R.; Xiao, L.; Blanchard, N.; Shi, W. Q.; Forsyth, C.; Hoepfner, D.; Spiess, M.; Park, E. s. Nature Chem. Biol. 2023, 19, 1063-1071.
Regio- and Stereoselective Hydroelementation of SF5-Alkynes and Further Functionalizations. Popek, L.; Cabrera-Trujillo, J. J.; Debrauwer, V.; Blanchard, N.; Miqueu, K.; Bizet, V. Angew. Chem. Int. Ed., 2023, 62, e202300685.
Radical Cyclization of Ynamides to Nitrogen Heterocycles. Zhang, C.; Blanchard, N.; Evano, G. Synthesis, 2023, 55, 272-288.
2022
Synthesis and further use of SF5-alkynes as platforms for the design of more complex SF5-containing products. Popek, L.; Nguyen, T. M.; Blanchard, N.; Cahard, D.; Bizet, V. Tetrahedron 2022, 117-118, 132814.
2021
Molecular mechanisms underpinning the circulation and cellular uptake of Mycobacterium ulcerans toxin mycolactone. Tello Rubio, B.; Bugault, F.; Baudon, B.; Raynal, B.; Brûlé, B.; Morel, J.-D.; Saint-Auret, S.; Blanchard, N.; Demangel C.; Guenin-Macé, L. Front. Pharmacol. - Experimental Pharmacology and Drug Discovery, 2021, 12, 733496
Synthesis and Physicochemical Properties of 2-SF5-(Aza)Indoles, a New Family of SF5 Heterocycles. Debrauwer, V.; Leito, I.; Lõkov, M.; Tshepelevitsh, S.; Parmentier, M.; Blanchard, N.; Bizet, V., ACS Org. & Inorg. Au 2021, 1, 43-50.
2020
Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system. Colucci-Guyon, E.; Rifflet, A.; Saint-Auret, S.; Blanchard, N.; da Costa, A.; Prehaud, C.; Levraud, J.-P.; Boneca, I.; Demangel, C.; Guenin-Macé, L. PLOS Negl. Trop. Dis., 2020, 14, e0008878.
Ligand-controlled regiodivergent palladium-catalyzed hydrogermylation of ynamides. Debrauwer, V.; Turlik, A.; Rummler, L.; Prescimone, A.; Blanchard, N.; Houk, K. N.; Bizet, V. J. Am. Chem. Soc. 2020, 142, 11153-11164.
Optimized synthesis of 7-aza-indazole by Diels-Alder cascade and associated process safety. Brach, N.; Le Fouler, V.; Bizet, V.; Lanz, M.; Hoehn, P.; Gallou, F.; Bailly, C.; Parmentier, M.; Blanchard, N. Org. Proc. Res. Dev. 2020, 24, 776-786.
DABCO-promoted diaryl thioether formation by catalytic coupling of sodium sulfinates and aryl iodides. Liu, Y.; La, L. Y.; Ye, J.; Blanchard, N., Ma, C. Adv. Synth. Catal. 2020, 362, 2326-2331.
Highlighted in Org. Proc. Res. Dev.: Zhao, W.; Guizzetti, S.; Schwindeman, J. A.; Daniels, D. S. B.; Douglas, J. J.; Petit, S.; Kelly, C. B.; Knight, J. Some Items of Interest to Process R&D Chemists and Engineers. Org. Proc. Res. Dev. 2020, 24, 885-896.
Pentafluorosulfanyl chloride. Burton, D. J; Wang, Y.; Bizet, V.; Cahard, D. e-EROS Encyclopedia of Reagents for Organic Synthesis. Wiley, 2020.
2019
Activating pyrimidines by pre-distortion for the general synthesis of 7-aza-indazoles from 2-hydrazonylpyrimidines via intramolecular Diels-Alder reactions. Le Fouler, V.; Chen, Y.; Gandon, V.; Bizet, V.; Salomé, C.; Fessard, T.; Liu, F.; Houk, K. N.; Blanchard, N. J. Am. Chem. Soc.2019, 141, 15901-15909.
Nusbiarylins, a New Class of Antimicrobial Agents: Rational Design of Bacterial Transcription Inhibitors Targeting the Interaction between the NusB and NusE Proteins. Qiu,Y; Chan, S.T.; Lin, L.; Shek, T. L.; Tsang, T. F.; Zhang, Y. ; Ip, M.; Chan, P. K.-s.; Blanchard, N.; Hanquet, G.; Zuo, Z.; Yang, X.; Ma, C. Bioorg. Chem.2019, 92, 103203.
Discussion Addendum for: Synthesis of Ynamides by Copper-Mediated Coupling of 1,1-Dibromo-1-alkenes with Nitrogen Nucleophiles. Preparation of 4-Methyl-N-(2-phenylethynyl)-N-(phenylmethyl)benzenesulfonamide. Theunissen, C.; Thilmany, P.; Lahboubi, M.; Blanchard, N.; Evano, G. Org. Synth.2019, 96, 195-213.
Recombinant Antibodies against Mycolactone. Naranjo, L.; Ferrara, F.; Blanchard, N.; Demangel, C.; D’Angelo, S.; Erasmus, F. M.; Teixera, A. A.; Bradbury, R. A Toxins 2019, 11, 346.
Design, synthesis and biological evaluation of antimicrobial diarylimine and –amine compounds targeting the interaction between the bacterial NusB and NusE proteins. Qiu, Y.; Chan, S. T.; Lin, L.; Shek, T. L.; Tsang, T. F.; Barua, N.; Zhang, Y.; Ip, M.; Chan, P. K.-s.; Blanchard, N.; Hanquet, G.; Zuo, Z.; Yang, X.; Ma, C. Eur. J. Med. Chem. 2019, 178, 214-231.
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation. Zong, G.; Hu, Z.; O’Keefe, S.; Tranter, D.; Iannotti, M. J.; Baron, L.; Hall, B.; Corfield, K.; Paatero, A. O.; Henderson, M. J.; Roboti, P.; Zhou, J.; Sun, X.; Govindarajan, M.; Rohde, J. M.; Blanchard, N.; Simmonds, R.; Inglese, J.; Du, Y.; Demangel, C.; High, S.; Paavilainen, V. O.; Shi, W. Q. J. Am. Chem. Soc. 2019, 141, 8450-8461.
Acid Fluorides in Transition-Metal Catalysis: A Good Balance between Stability and Reactivity. Blanchard, N., Bizet, V. Angew. Chem. Int. Ed. 2019, 58, 6814-6817.
Ruthenium-Catalyzed Ring-Opening Reaction of a 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene with Amines. Tait, K.; Koh, S.; Blanchard, N. Tam, W. Can. J. Chem. 2019, 97, 310-316.
2018
Copper-mediated synthesis of N-vinyl ynamides from N-vinyl carbamates. Le Fouler, V.; Duret, G.; Bisseret, P.; Blanchard, N. Tetrahedron Lett. 2018, 59, 3349-3352.
Novel applications of fluorescent brighteners in aqueous visible-light photopolymerization: high performance water-based coating and LED-assisted hydrogel synthesis; Zuo, X.; Morlet-Savary, F.; Schmitt, M.; Le Nouën, D.; Blanchard, N.; Goddard, J.-P.; Lalevée, J. Polymer Chem.2018, 9, 3952-3958.
Aryl transition metal chemical warheads for protein bioconjugation. Bisseret, P.; Abdelkafi, H.; Blanchard, N. Chem. Sci.2018, 9, 5132-5144.